top of page


Copper-Catalyzed Dearomative 1,2-Hydroamination

C. W. Davis, Y. Zhang, Y. Li, M. Martinelli, J. Zhang, C. Ungarean, P. Galer, P. Liu, D. Sarlah

Angew. Chem. Int. Ed. 2024, e202407281


Copper-Catalyzed Dearomative trans-1,2-Carboamination

C. W. Davis, Y. Li, Y. Zhang, Z. Siddiqi, P. Liu, D. Sarlah

ACS Catal. 2024, ASAP


Oxidative Dearomatization of Pyridines

Z. Siddiqi, T. W. Bingham, T. Shimakawa, K. D. Hesp, A. Shavnya, D. Sarlah

J. Am. Chem. Soc. 2024, 146, 2358–2363


Diversification of Simple Arenes into Complex (Amino)cyclitols

E. Angelini, M. Martinelli, E. Roà, C. N. Ungarean, C. Salome, Q. Lefebvre, C. Bournez, T. C. Fessard, D. Sarlah

Chem. Eur. J. 2023, e202303262


Dewar Pyridines: Conformationally Programmable Piperidine Isosteres

J. Petrovcic, D, Y. Boyko.; A. S. Shved, G. Lenardon, C. Salome, Q. Lefebvre, T. Fessard, D. Sarlah

ChemRxiv May 25, 2023


Total Syntheses of Scabrolide A and Yonarolide

R. Serrano, Y. D. Boyko, L. W. Hernandez, A. Lotuzas, D. Sarlah

J. Am. Chem. Soc. 2023, 145, 8805–8809


Genome Mining Unveils a Class of Ribosomal Peptides with Two Amino Termini

H. Ren, S. R. Dommaraju, C. Huang, H. Cui, Y. Pan, M. Nesic, L. Zhu, D. Sarlah, D. A. Mitchell, H. Zhao

Nat. Commun. 2023, 14, 1624


π-Extended Rubrenes via Dearomative Annulative π-Extension Reaction

W. Matsuoka, K. P. Kawahara, H. Ito, D. Sarlah, K. Itami

J. Am. Chem. Soc. 2023, 145, 658–666


Metabolites of Cannabigerol Generated by Human Cytochrome P450s Are Bioactive

P. Roy, D. G. Dennis, M. D. Eschbach, S. D. Anand, F. Xu, J. Maturano, J. Hellman, D. Sarlah, A. Das

Biochemistry 2022, 61, 2398–2408


Dearomative Logic in Natural Product Total Synthesis

C. J. Huck, Y. D. Boyko, D. Sarlah

Natural Product Reports, 2022, 39, 2336–2337


Bioinspired Total Synthesis of Pyritide A2 through Pyridine Ring Synthesis

A. R. Hooper, A. Ostrek, A. Milian-Lopez, D. Sarlah

Angew. Chem. Int. Ed. 2022, 61, e202212299


Dearomative Ring Expansion of Polycyclic Arenes

P. Piacentini, T. W. Bingham, D. Sarlah

Angew. Chem. Int. Ed. 2022, 61, e202208014


Total Synthesis of Darobactin A

M. Nesic, D. B. Ryffel, J. Maturano, M. Shevlin, S. R. Pollack, D. R. Gauthier Jr., P. Trigo-Mourino, L.-K. Zhang, D. M. Schultz, J. M. McCabe Dunn, L.-C. Campeau, N. R. Patel, D. A. Petrone, D. Sarlah

J. Am. Chem. Soc. 2022, 144, 14026–14030


Synthesis of (+)-Ribostamycin by Catalytic, Enantioselective Hydroamination of Benzene

C. N. Ungarean, P. Galer, Y. Zhang, K. S. Lee, J. M. Ngai, S. Lee, P. Liu, D. Sarlah

Nature Synthesis 2022, 1, 542-547


Synthesis of the Cannabimovone and Cannabifuran Class of Minor Phytocannabinoids and Their Anti-inflammatory Activity

D. G. Dennis, S. D. Anand, A. J. Lopez, J. Petrovcic, A. Das, D. Sarlah

J. Org. Chem. 2022, 87, 6075–6086


Electrochemical Dearomatization of Commodity Polymers

Z. Siddiqi, D. Sarlah

J. Am. Chem. Soc. 2021, 143, 21264–21269


Amaryllidaceae Isocarbostyril Alkaloids

T.W. Bingham, L. W. Hernandez, D. Sarlah

Strategies and Tactics in Organic Synthesis, 2021, 15, 1-52


Dearomative syn-1,2-Diamination of Benzene and Naphthalene

C. W. Davis, T. W. Bingham, M. Okumura, D. Sarlah

Synthesis, 2021, 53, 4290-4296


Diversity-Oriented Synthesis of Nanographenes Enabled by Dearomative Annulative π-Extension

W. Matsuoka, H. Ita, D. Sarlah, K. Itami

Nature Commun., 2021, 12, 3940


Encyclopedia of Reagents for Organic Synthesis: 4-Methyl-1,2,4-triazoline-3,5-dione (MTAD)

M. Okumura, D. Sarlah

e-EROS. 2021, 1-11


Total Synthesis and Computational Investigations of Sesquiterpene-Tropolones Ameliorate Stereochemical Inconsistencies and Resolve an Ambiguous Biosynthetic Relationship

C. Y. Bemis, C. N. Ungarean, A. S. Shved, C. S. Jamieson, T. Hwang, K. S. Lee, K. N. Houk, and D. Sarlah

J. Am. Chem. Soc. 2021, 143, 6006–6017


Total Synthesis of Stelletins through an Unconventional Annulation Strategy

C. J. Huck, Y. D. Boyko, D. Sarlah

Acc. Chem. Res. 2021, 54, 1597–1609


Synthetic Studies on Selective, Proapoptotic Isomalabaricane Triterpenoids Aided by Computational Techniques

Y. Boyko, C. J. Huck, S. Ning, A. S. Shved, C. Yang, T. Chu, E. J. Tonogai, P. J. Hergenrother, D. Sarlah

J. Am. Chem. Soc. 2021, 143, 2138–2155


Development of a Scalable and Sublimation-Free Route to MTAD

Z. Siddiqi, C. N. Ungarean, T. W. Bingham, D. Sarlah

Org. Process Res. Dev. 2020, 24, 2953–2959


Structure Prediction and Synthesis of Pyridine-Based Macrocyclic Peptide Natural Products

G. A. Hudson, A. R. Hooper, A. J. DiCaprio, D. Sarlah, D. A. Mitchell

Org. Lett. 2021, 23, 253–256


Arenophile-Mediated Photochemical Dearomatization of Nonactivated Arenes

M. Okumura, D. Sarlah

CHIMIA 2020, 74, 577-583


Shaping Molecular Landscapes: Recent Advances, Opportunities, and Challenges in Dearomatization

C. J. Huck, D. Sarlah

Chem 2020, 6, 1589-1603


A New Approach Towards The Synthesis of Bielschowskysin: Synthesis and Photochemistry of An Advanced Macrocyclic Enedione Intermediate

M. Nesic, M. M. Kincanon, D. B. Ryffel, D. Sarlah

Tetrahedron, 2020, 131318


Chemical Equivalent of Arene Monooxygenases: Dearomative Synthesis of Arene Oxides and Oxepines

Z. Siddiqi, W. C. Wertjes, D. Sarlah

J. Am. Chem. Soc. 2020, 142, 10125–10131


Visible-Light-Induced Dearomatizations

M. Okumura, D. Sarlah

Eur. J. Org. Chem. 2020, 10, 1259-1273


Palladium‐Catalyzed Dearomative syn‐1,4‐Oxyamination

C. Tang, M. Okumura, H. Deng, D. Sarlah

Angew. Chem. Int. Ed. 2019, 58, 15762–15766


The Total Synthesis of Isomalabaricane Triterpenoids

Y. Boyko, C. J. Huck, D. Sarlah

J. Am. Chem. Soc. 2019, 141, 14131–14135


Empowering Synthesis of Complex Natural Products

L. W. Hernandez, D. Sarlah

Chem. Eur. J. 2019, 25, 13248–13270


Palladium‐Catalyzed Dearomative syn‐1,4‐Carboamination with Grignard Reagents

C. Tang, M. Okumura, Y. Zhu, A. Hooper, Y. Lee, D. Sarlah

Angew. Chem. Int. Ed. 2019, 58, 10245–10249


Synthesis of Idarubicinone via Global Functionalization of Tetracene

D. G. Dennis, M. Okumura, D. Sarlah

J. Am. Chem. Soc. 2019, 141, 10193–10198


Palladium-Catalyzed Dearomative syn-1,4-Diamination

W. C. Wertjes, M. Okumura, D. Sarlah

J. Am. Chem. Soc. 2019, 141, 163–167


Enantioselective Synthesis of Isocarbostyril Alkaloids and Analogs Using Catalytic Dearomative Functionalization of Benzene

T. W. Bingham, L. W. Hernandez, D. G. Olson, R. L. Svec, P. J. Hergenrother, D. Sarlah

J. Am. Chem. Soc. 2019, 141, 657–670


Recent advances in chemical dearomatization of nonactivated arenes

W. C. Wertjes, E. H. Southgate, D. Sarlah

Chem. Soc. Rev. 2018, 47, 7996–8017


Nickel-Catalyzed Dearomative trans-1,2-Carboamination

L. W. Hernandez, U. Klöckner, J. Pospech, L. Hauss, D. Sarlah

J. Am. Chem. Soc. 2018, 140, 4503–4507


Arenophile-Mediated Dearomative Functionalization Strategies

M. Okumura, D. Sarlah

Synlett 2018, 29, 845–855


Palladium-Catalyzed Dearomative syn-1,4-Carboamination

M. Okumura, A. S. Shved, D. Sarlah

J. Am. Chem. Soc. 2017, 139, 17787–17790


Synthesis of (+)-Pancratistatins via Catalytic Desymmetrization of Benzene

L. W. Hernandez, J. Pospech, U. Kloeckner, T. W. Bingham, D. Sarlah

J. Am. Chem. Soc. 2017, 139, 15656–15659


Total Synthesis of Lycoricidine and Narciclasine by Chemical Dearomatization of Bromobenzene /Review article/

E. H. Southgate, D. R. Holycross, D. Sarlah

Angew. Chem. Int. Ed. 2017, 56, 15049–15052


Arenophile-Mediated Dearomative Reduction

M. Okumura, S. M. Nakamata Huynh, J. Pospech, D. Sarlah

Angew. Chem. Int. Ed. 2016, 55, 15910–15914


Dearomative Dihydroxylation with Arenophiles

E. H. Southgate, J. Pospech, J. Fu, D. R. Holycross, D. Sarlah

Nature Chem. 2016, 8, 922–928


Enantioselective Polyene Cyclizations

C. N. Ungarean, E. H. Southgate, D. Sarlah

Org. Biomol. Chem. 2016, 14, 5454–5467

bottom of page