Publications

Stereodivergent Construction of trans-Decalin-Based Terpenoids

Samantha L. Barlock, Alexander S. Shved, Kayla D. Landers, Binh Khanh Mai, Shogo Fujiki,
Peter C. Ryffel, Wai Yam Lo, Andrew G. Feng, Nicholas W. Wade, Lingyang Zhu, Viet D. Nguyen,
David A. Petrone, Scott E. Denmark, and David Sarlah

J. Am. Chem. Soc. 2026, 148, 13391–13403

Screenshot 2026-03-27 at 6.50_edited.jpg

A Versatile Enzymatic Pathway for Modification of Peptide C-Termini

S. R. Dommaraju, S. K. Kandy, H. Ren, D. P. Luciano, S. Fujiki, D. Sarlah, H. Zhao, J. R. Chekan, D. A. Mitchell

ACS Cent. Sci. 2025, 11, 2143–2153

Enantioselective Total Syntheses of Sannamycins A and B

J. Zhang, T. Shimakawa, C. N. Ungarean, S. Lee, Q. Zhu, S. Zhong, D. Sarlah

J. Am. Chem. Soc. 2025, 147, 31476–31481

Stereodivergent Synthesis of Perhydrobenz[e]indene Terpenoids

C. Yang, C. J. Huck, Y. D. Boyko, S. Ning, U. Vezonik, A. S. Shved, S. E. Denmark, B. K. Mai, D. Sarlah

J. Am. Chem. Soc. 2025, 147, 24847–24856

Stereoselective Total Synthesis of Nimbolide

D. B. Ryffel, P. C. Ryffel, M. Martinelli, V. R. Pillai, D Sarlah

J. Am. Chem. Soc. 2025, 147, 17, 14083–14087

Reimagining Dearomatization: Arenophile-Mediated Single-Atom Insertions and π-Extensions

Z. Siddiqi, D. Sarlah

Acc. Chem. Res. 2025, 58, 1134-1150

Total Syntheses of Scabrolide B, Ineleganolide, and Related Norcembranoids

E. J. Simmons, D. B. Ryffel, D. A. Lopez, Y. D. Boyko, D. Sarlah

J. Am. Chem. Soc. 2025, 147, 130–135

Asymmetric Synthesis of β,β-Disubstituted Alanines via a Sequential C(sp2)–C(sp3) Cross-Coupling–Hydrogenation Strategy

D. A. Petrone, J. Maturano, J. Herbort, E. E. Plasek, J. M. Vivaldo-Nikitovic, D. Sarlah

Org. Lett. 2024, 26, 6284–6289

Palladium-catalyzed Dearomative 1,4-Hydroamination

R. Gilbert, C. W. Davis, T. W. Bingham, D. Sarlah

Tetrahedron, 2024, 163, 134135

Copper-Catalyzed Dearomative 1,2-Hydroamination

C. W. Davis, Y. Zhang, Y. Li, M. Martinelli, J. Zhang, C. Ungarean, P. Galer, P. Liu, D. Sarlah

Angew. Chem. Int. Ed. 2024, e202407281

Copper-Catalyzed Dearomative trans-1,2-Carboamination

C. W. Davis, Y. Li, Y. Zhang, Z. Siddiqi, P. Liu, D. Sarlah

ACS Catal. 2024, 14, 10132–10137

Oxidative Dearomatization of Pyridines

Z. Siddiqi, T. W. Bingham, T. Shimakawa, K. D. Hesp, A. Shavnya, D. Sarlah

J. Am. Chem. Soc. 2024, 146, 2358–2363

Diversification of Simple Arenes into Complex (Amino)cyclitols

E. Angelini, M. Martinelli, E. Roà, C. N. Ungarean, C. Salome, Q. Lefebvre, C. Bournez, T. C. Fessard, D. Sarlah

Chem. Eur. J. 2023, e202303262

Dewar Pyridines: Conformationally Programmable Piperidine Isosteres

J. Petrovcic, D, Y. Boyko.; A. S. Shved, G. Lenardon, C. Salome, Q. Lefebvre, T. Fessard, D. Sarlah

ChemRxiv May 25, 2023

Total Syntheses of Scabrolide A and Yonarolide

R. Serrano, Y. D. Boyko, L. W. Hernandez, A. Lotuzas, D. Sarlah

J. Am. Chem. Soc. 2023, 145, 8805–8809

Genome Mining Unveils a Class of Ribosomal Peptides with Two Amino Termini

H. Ren, S. R. Dommaraju, C. Huang, H. Cui, Y. Pan, M. Nesic, L. Zhu, D. Sarlah, D. A. Mitchell, H. Zhao

Nat. Commun. 2023, 14, 1624

π-Extended Rubrenes via Dearomative Annulative π-Extension Reaction

W. Matsuoka, K. P. Kawahara, H. Ito, D. Sarlah, K. Itami

J. Am. Chem. Soc. 2023, 145, 658–666

Metabolites of Cannabigerol Generated by Human Cytochrome P450s Are Bioactive

P. Roy, D. G. Dennis, M. D. Eschbach, S. D. Anand, F. Xu, J. Maturano, J. Hellman, D. Sarlah, A. Das

Biochemistry 2022, 61, 2398–2408

Dearomative Logic in Natural Product Total Synthesis

C. J. Huck, Y. D. Boyko, D. Sarlah

Natural Product Reports, 2022, 39, 2336–2337

Bioinspired Total Synthesis of Pyritide A2 through Pyridine Ring Synthesis

A. R. Hooper, A. Ostrek, A. Milian-Lopez, D. Sarlah

Angew. Chem. Int. Ed. 2022, 61, e202212299

Dearomative Ring Expansion of Polycyclic Arenes

P. Piacentini, T. W. Bingham, D. Sarlah

Angew. Chem. Int. Ed. 2022, 61, e202208014

Total Synthesis of Darobactin A

M. Nesic, D. B. Ryffel, J. Maturano, M. Shevlin, S. R. Pollack, D. R. Gauthier Jr., P. Trigo-Mourino, L.-K. Zhang, D. M. Schultz, J. M. McCabe Dunn, L.-C. Campeau, N. R. Patel, D. A. Petrone, D. Sarlah

J. Am. Chem. Soc. 2022, 144, 14026–14030

Synthesis of (+)-Ribostamycin by Catalytic, Enantioselective Hydroamination of Benzene

C. N. Ungarean, P. Galer, Y. Zhang, K. S. Lee, J. M. Ngai, S. Lee, P. Liu, D. Sarlah

Nature Synthesis 2022, 1, 542-547

Synthesis of the Cannabimovone and Cannabifuran Class of Minor Phytocannabinoids and Their Anti-inflammatory Activity

D. G. Dennis, S. D. Anand, A. J. Lopez, J. Petrovcic, A. Das, D. Sarlah

J. Org. Chem. 2022, 87, 6075–6086

Electrochemical Dearomatization of Commodity Polymers

Z. Siddiqi, D. Sarlah

J. Am. Chem. Soc. 2021, 143, 21264–21269

Amaryllidaceae Isocarbostyril Alkaloids

T.W. Bingham, L. W. Hernandez, D. Sarlah

Strategies and Tactics in Organic Synthesis, 2021, 15, 1-52

Dearomative syn-1,2-Diamination of Benzene and Naphthalene

C. W. Davis, T. W. Bingham, M. Okumura, D. Sarlah

Synthesis, 2021, 53, 4290-4296

Diversity-Oriented Synthesis of Nanographenes Enabled by Dearomative Annulative π-Extension

W. Matsuoka, H. Ita, D. Sarlah, K. Itami

Nature Commun., 2021, 12, 3940

Encyclopedia of Reagents for Organic Synthesis: 4-Methyl-1,2,4-triazoline-3,5-dione (MTAD)

M. Okumura, D. Sarlah

e-EROS. 2021, 1-11

Total Synthesis and Computational Investigations of Sesquiterpene-Tropolones Ameliorate Stereochemical Inconsistencies and Resolve an Ambiguous Biosynthetic Relationship

C. Y. Bemis, C. N. Ungarean, A. S. Shved, C. S. Jamieson, T. Hwang, K. S. Lee, K. N. Houk, and D. Sarlah

J. Am. Chem. Soc. 2021, 143, 6006–6017

Total Synthesis of Stelletins through an Unconventional Annulation Strategy

C. J. Huck, Y. D. Boyko, D. Sarlah

Acc. Chem. Res. 2021, 54, 1597–1609

Synthetic Studies on Selective, Proapoptotic Isomalabaricane Triterpenoids Aided by Computational Techniques

Y. Boyko, C. J. Huck, S. Ning, A. S. Shved, C. Yang, T. Chu, E. J. Tonogai, P. J. Hergenrother, D. Sarlah

J. Am. Chem. Soc. 2021, 143, 2138–2155

Development of a Scalable and Sublimation-Free Route to MTAD

Z. Siddiqi, C. N. Ungarean, T. W. Bingham, D. Sarlah

Org. Process Res. Dev. 2020, 24, 2953–2959

Structure Prediction and Synthesis of Pyridine-Based Macrocyclic Peptide Natural Products

G. A. Hudson, A. R. Hooper, A. J. DiCaprio, D. Sarlah, D. A. Mitchell

Org. Lett. 2021, 23, 253–256

Arenophile-Mediated Photochemical Dearomatization of Nonactivated Arenes

M. Okumura, D. Sarlah

CHIMIA 2020, 74, 577-583

Shaping Molecular Landscapes: Recent Advances, Opportunities, and Challenges in Dearomatization

C. J. Huck, D. Sarlah

Chem 2020, 6, 1589-1603

A New Approach Towards The Synthesis of Bielschowskysin: Synthesis and Photochemistry of An Advanced Macrocyclic Enedione Intermediate

M. Nesic, M. M. Kincanon, D. B. Ryffel, D. Sarlah

Tetrahedron, 2020, 131318

Chemical Equivalent of Arene Monooxygenases: Dearomative Synthesis of Arene Oxides and Oxepines

Z. Siddiqi, W. C. Wertjes, D. Sarlah

J. Am. Chem. Soc. 2020, 142, 10125–10131

Visible-Light-Induced Dearomatizations

M. Okumura, D. Sarlah

Eur. J. Org. Chem. 2020, 10, 1259-1273

Palladium‐Catalyzed Dearomative syn‐1,4‐Oxyamination

C. Tang, M. Okumura, H. Deng, D. Sarlah

Angew. Chem. Int. Ed. 2019, 58, 15762–15766

The Total Synthesis of Isomalabaricane Triterpenoids

Y. Boyko, C. J. Huck, D. Sarlah

J. Am. Chem. Soc. 2019, 141, 14131–14135

Empowering Synthesis of Complex Natural Products

L. W. Hernandez, D. Sarlah

Chem. Eur. J. 2019, 25, 13248–13270

Palladium‐Catalyzed Dearomative syn‐1,4‐Carboamination with Grignard Reagents

C. Tang, M. Okumura, Y. Zhu, A. Hooper, Y. Lee, D. Sarlah

Angew. Chem. Int. Ed. 2019, 58, 10245–10249

Synthesis of Idarubicinone via Global Functionalization of Tetracene

D. G. Dennis, M. Okumura, D. Sarlah

J. Am. Chem. Soc. 2019, 141, 10193–10198

Palladium-Catalyzed Dearomative syn-1,4-Diamination

W. C. Wertjes, M. Okumura, D. Sarlah

J. Am. Chem. Soc. 2019, 141, 163–167

Enantioselective Synthesis of Isocarbostyril Alkaloids and Analogs Using Catalytic Dearomative Functionalization of Benzene

T. W. Bingham, L. W. Hernandez, D. G. Olson, R. L. Svec, P. J. Hergenrother, D. Sarlah

J. Am. Chem. Soc. 2019, 141, 657–670

Recent advances in chemical dearomatization of nonactivated arenes

W. C. Wertjes, E. H. Southgate, D. Sarlah

Chem. Soc. Rev. 2018, 47, 7996–8017

Nickel-Catalyzed Dearomative trans-1,2-Carboamination

L. W. Hernandez, U. Klöckner, J. Pospech, L. Hauss, D. Sarlah

J. Am. Chem. Soc. 2018, 140, 4503–4507

Arenophile-Mediated Dearomative Functionalization Strategies

M. Okumura, D. Sarlah

Synlett 2018, 29, 845–855

Palladium-Catalyzed Dearomative syn-1,4-Carboamination

M. Okumura, A. S. Shved, D. Sarlah

J. Am. Chem. Soc. 2017, 139, 17787–17790

Synthesis of (+)-Pancratistatins via Catalytic Desymmetrization of Benzene

L. W. Hernandez, J. Pospech, U. Kloeckner, T. W. Bingham, D. Sarlah

J. Am. Chem. Soc. 2017, 139, 15656–15659

Total Synthesis of Lycoricidine and Narciclasine by Chemical Dearomatization of Bromobenzene

E. H. Southgate, D. R. Holycross, D. Sarlah

Angew. Chem. Int. Ed. 2017, 56, 15049–15052

Arenophile-Mediated Dearomative Reduction

M. Okumura, S. M. Nakamata Huynh, J. Pospech, D. Sarlah

Angew. Chem. Int. Ed. 2016, 55, 15910–15914

Dearomative Dihydroxylation with Arenophiles

E. H. Southgate, J. Pospech, J. Fu, D. R. Holycross, D. Sarlah

Nature Chem. 2016, 8, 922–928

Enantioselective Polyene Cyclizations

C. N. Ungarean, E. H. Southgate, D. Sarlah

Org. Biomol. Chem. 2016, 14, 5454–5467

For full list of publications, see Google Scholar

Publications

Contacts

Rice University
Department of Chemistry
MS-60, 341 DBH
Houston, TX 77005

sarlah@rice.edu

Publications

Contacts

Rice University Department of Chemistry MS-60, 341 DBH Houston, TX 77005

sarlah@rice.edu

Rice University
Department of Chemistry
MS-60, 341 DBH
Houston, TX 77005