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Publications

Oxidative Dearomatization of Pyridines

Z. Siddiqi, T. W. Bingham, T. Shimakawa, K. D. Hesp, A. Shavnya, D. Sarlah

J. Am. Chem. Soc. 2024, 146, 2358–2363

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Diversification of Simple Arenes into Complex (Amino)cyclitols

E. Angelini, M. Martinelli, E. Roà, C. N. Ungarean, C. Salome, Q. Lefebvre, C. Bournez, T. C. Fessard, D. Sarlah

Chem. Eur. J. 2023, e202303262

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Dewar Pyridines: Conformationally Programmable Piperidine Isosteres

J. Petrovcic, D, Y. Boyko.; A. S. Shved, G. Lenardon, C. Salome, Q. Lefebvre, T. Fessard, D. Sarlah

ChemRxiv May 25, 2023

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Total Syntheses of Scabrolide A and Yonarolide

R. Serrano, Y. D. Boyko, L. W. Hernandez, A. Lotuzas, D. Sarlah

J. Am. Chem. Soc. 2023, 145, 8805–8809

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Genome Mining Unveils a Class of Ribosomal Peptides with Two Amino Termini

H. Ren, S. R. Dommaraju, C. Huang, H. Cui, Y. Pan, M. Nesic, L. Zhu, D. Sarlah, D. A. Mitchell, H. Zhao

Nat. Commun. 2023, 14, 1624

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π-Extended Rubrenes via Dearomative Annulative π-Extension Reaction

W. Matsuoka, K. P. Kawahara, H. Ito, D. Sarlah, K. Itami

J. Am. Chem. Soc. 2023, 145, 658–666

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Metabolites of Cannabigerol Generated by Human Cytochrome P450s Are Bioactive

P. Roy, D. G. Dennis, M. D. Eschbach, S. D. Anand, F. Xu, J. Maturano, J. Hellman, D. Sarlah, A. Das

Biochemistry 2022, 61, 2398–2408

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Dearomative Logic in Natural Product Total Synthesis

C. J. Huck, Y. D. Boyko, D. Sarlah

Natural Product Reports, 2022, 39, 2336–2337

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Bioinspired Total Synthesis of Pyritide A2 through Pyridine Ring Synthesis

A. R. Hooper, A. Ostrek, A. Milian-Lopez, D. Sarlah

Angew. Chem. Int. Ed. 2022, 61, e202212299

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Dearomative Ring Expansion of Polycyclic Arenes

P. Piacentini, T. W. Bingham, D. Sarlah

Angew. Chem. Int. Ed. 2022, 61, e202208014

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Total Synthesis of Darobactin A

M. Nesic, D. B. Ryffel, J. Maturano, M. Shevlin, S. R. Pollack, D. R. Gauthier Jr., P. Trigo-Mourino, L.-K. Zhang, D. M. Schultz, J. M. McCabe Dunn, L.-C. Campeau, N. R. Patel, D. A. Petrone, D. Sarlah

J. Am. Chem. Soc. 2022, 144, 14026–14030

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Synthesis of (+)-Ribostamycin by Catalytic, Enantioselective Hydroamination of Benzene

C. N. Ungarean, P. Galer, Y. Zhang, K. S. Lee, J. M. Ngai, S. Lee, P. Liu, D. Sarlah

Nature Synthesis 2022, 1, 542-547

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Synthesis of the Cannabimovone and Cannabifuran Class of Minor Phytocannabinoids and Their Anti-inflammatory Activity

D. G. Dennis, S. D. Anand, A. J. Lopez, J. Petrovcic, A. Das, D. Sarlah

J. Org. Chem. 2022, 87, 6075–6086

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Electrochemical Dearomatization of Commodity Polymers

Z. Siddiqi, D. Sarlah

J. Am. Chem. Soc. 2021, 143, 21264–21269

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Amaryllidaceae Isocarbostyril Alkaloids

T.W. Bingham, L. W. Hernandez, D. Sarlah

Strategies and Tactics in Organic Synthesis, 2021, 15, 1-52

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Dearomative syn-1,2-Diamination of Benzene and Naphthalene

C. W. Davis, T. W. Bingham, M. Okumura, D. Sarlah

Synthesis, 2021, 53, 4290-4296

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Diversity-Oriented Synthesis of Nanographenes Enabled by Dearomative Annulative π-Extension

W. Matsuoka, H. Ita, D. Sarlah, K. Itami

Nature Commun., 2021, 12, 3940

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Encyclopedia of Reagents for Organic Synthesis: 4-Methyl-1,2,4-triazoline-3,5-dione (MTAD)

M. Okumura, D. Sarlah

e-EROS. 2021, 1-11

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Total Synthesis and Computational Investigations of Sesquiterpene-Tropolones Ameliorate Stereochemical Inconsistencies and Resolve an Ambiguous Biosynthetic Relationship

C. Y. Bemis, C. N. Ungarean, A. S. Shved, C. S. Jamieson, T. Hwang, K. S. Lee, K. N. Houk, and D. Sarlah

J. Am. Chem. Soc. 2021, 143, 6006–6017

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Total Synthesis of Stelletins through an Unconventional Annulation Strategy

C. J. Huck, Y. D. Boyko, D. Sarlah

Acc. Chem. Res. 2021, 54, 1597–1609

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Synthetic Studies on Selective, Proapoptotic Isomalabaricane Triterpenoids Aided by Computational Techniques

Y. Boyko, C. J. Huck, S. Ning, A. S. Shved, C. Yang, T. Chu, E. J. Tonogai, P. J. Hergenrother, D. Sarlah

J. Am. Chem. Soc. 2021, 143, 2138–2155

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Development of a Scalable and Sublimation-Free Route to MTAD

Z. Siddiqi, C. N. Ungarean, T. W. Bingham, D. Sarlah

Org. Process Res. Dev. 2020, 24, 2953–2959

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Structure Prediction and Synthesis of Pyridine-Based Macrocyclic Peptide Natural Products

G. A. Hudson, A. R. Hooper, A. J. DiCaprio, D. Sarlah, D. A. Mitchell

Org. Lett. 2021, 23, 253–256

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Arenophile-Mediated Photochemical Dearomatization of Nonactivated Arenes

M. Okumura, D. Sarlah

CHIMIA 2020, 74, 577-583

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Shaping Molecular Landscapes: Recent Advances, Opportunities, and Challenges in Dearomatization

C. J. Huck, D. Sarlah

Chem 2020, 6, 1589-1603

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A New Approach Towards The Synthesis of Bielschowskysin: Synthesis and Photochemistry of An Advanced Macrocyclic Enedione Intermediate

M. Nesic, M. M. Kincanon, D. B. Ryffel, D. Sarlah

Tetrahedron, 2020, 131318

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Chemical Equivalent of Arene Monooxygenases: Dearomative Synthesis of Arene Oxides and Oxepines

Z. Siddiqi, W. C. Wertjes, D. Sarlah

J. Am. Chem. Soc. 2020, 142, 10125–10131

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Visible-Light-Induced Dearomatizations

M. Okumura, D. Sarlah

Eur. J. Org. Chem. 2020, 10, 1259-1273

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Palladium‐Catalyzed Dearomative syn‐1,4‐Oxyamination

C. Tang, M. Okumura, H. Deng, D. Sarlah

Angew. Chem. Int. Ed. 2019, 58, 15762–15766

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The Total Synthesis of Isomalabaricane Triterpenoids

Y. Boyko, C. J. Huck, D. Sarlah

J. Am. Chem. Soc. 2019, 141, 14131–14135

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Empowering Synthesis of Complex Natural Products

L. W. Hernandez, D. Sarlah

Chem. Eur. J. 2019, 25, 13248–13270

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Palladium‐Catalyzed Dearomative syn‐1,4‐Carboamination with Grignard Reagents

C. Tang, M. Okumura, Y. Zhu, A. Hooper, Y. Lee, D. Sarlah

Angew. Chem. Int. Ed. 2019, 58, 10245–10249

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Synthesis of Idarubicinone via Global Functionalization of Tetracene

D. G. Dennis, M. Okumura, D. Sarlah

J. Am. Chem. Soc. 2019, 141, 10193–10198

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Palladium-Catalyzed Dearomative syn-1,4-Diamination

W. C. Wertjes, M. Okumura, D. Sarlah

J. Am. Chem. Soc. 2019, 141, 163–167

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Enantioselective Synthesis of Isocarbostyril Alkaloids and Analogs Using Catalytic Dearomative Functionalization of Benzene

T. W. Bingham, L. W. Hernandez, D. G. Olson, R. L. Svec, P. J. Hergenrother, D. Sarlah

J. Am. Chem. Soc. 2019, 141, 657–670

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Recent advances in chemical dearomatization of nonactivated arenes

W. C. Wertjes, E. H. Southgate, D. Sarlah

Chem. Soc. Rev. 2018, 47, 7996–8017

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Nickel-Catalyzed Dearomative trans-1,2-Carboamination

L. W. Hernandez, U. Klöckner, J. Pospech, L. Hauss, D. Sarlah

J. Am. Chem. Soc. 2018, 140, 4503–4507

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Arenophile-Mediated Dearomative Functionalization Strategies

M. Okumura, D. Sarlah

Synlett 2018, 29, 845–855

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Palladium-Catalyzed Dearomative syn-1,4-Carboamination

M. Okumura, A. S. Shved, D. Sarlah

J. Am. Chem. Soc. 2017, 139, 17787–17790

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Synthesis of (+)-Pancratistatins via Catalytic Desymmetrization of Benzene

L. W. Hernandez, J. Pospech, U. Kloeckner, T. W. Bingham, D. Sarlah

J. Am. Chem. Soc. 2017, 139, 15656–15659

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Total Synthesis of Lycoricidine and Narciclasine by Chemical Dearomatization of Bromobenzene /Review article/

E. H. Southgate, D. R. Holycross, D. Sarlah

Angew. Chem. Int. Ed. 2017, 56, 15049–15052

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Arenophile-Mediated Dearomative Reduction

M. Okumura, S. M. Nakamata Huynh, J. Pospech, D. Sarlah

Angew. Chem. Int. Ed. 2016, 55, 15910–15914

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Dearomative Dihydroxylation with Arenophiles

E. H. Southgate, J. Pospech, J. Fu, D. R. Holycross, D. Sarlah

Nature Chem. 2016, 8, 922–928

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Enantioselective Polyene Cyclizations

C. N. Ungarean, E. H. Southgate, D. Sarlah

Org. Biomol. Chem. 2016, 14, 5454–5467

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